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please call 1-800-721-8909.
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Call 1-844-EMPLICITI (1-844-367-5424)
BMS Access Support®

This site is intended for U.S. residents 18 years of age or older.


WHAT IS EMPLICITI® (elotuzumab)?

EMPLICITI is a prescription medicine used to treat multiple myeloma in combination with the medicines:

  • Revlimid® (lenalidomide) and dexamethasone in adults who have received one to three prior treatments for their multiple myeloma.
  • Pomalyst® (pomalidomide) and dexamethasone in adults who have received at least two prior treatments including Revlimid and a proteasome inhibitor.

It is not known if EMPLICITI is safe and effective in children.


Dinah G., EMPLICITI patient. Susan, Dinah’s caregiver. Dinah takes EMPLICITI +
Pomalyst® (pomalidomide) + dexamethasone.



There’s a story behind every selfie. Some EMPLICITI patients and their loved ones have shared their personal stories to help encourage others fighting relapsed/refractory multiple myeloma. Click below to hear from real EMPLICITI patients taking EMPLICITI + Pomalyst® (pomalidomide) + dexamethasone (EPd) or EMPLICITI + Revlimid® (lenalidomide) + dexamethasone (ERd).

    • Video thumbnail of EMPLICITI® (elotuzumab) patient, Angela. Angela takes EMPLICITI® (elotuzumab) + Revlimid® (lenalidomide) + dexamethasone. ANGELA’S STORY
    • Video thumbnail of EMPLICITI® (elotuzumab) patient, Rick N. and his wife, Denise. Rick takes EMPLICITI® (elotuzumab) + Revlimid® (lenalidomide) + dexamethasone. RICK’S STORY
    • Video thumbnail of EMPLICITI® (elotuzumab) patient, Randy. Randy takes EMPLICITI® (elotuzumab) + Revlimid® (lenalidomide) + dexamethasone. RANDY’S STORY
Video thumbnail of EMPLICITI® (elotuzumab) patient, Dinah. Dinah takes EMPLICITI® (elotuzumab) + Pomalyst® (pomalidomide) + dexamethasone.

Dinah's Story EMPLICITI PATIENTDinah takes EMPLICITI + Pomalyst® (pomalidomide) + dexamethasone


I had actually gone to my doctor with something that had nothing to do with myeloma or anything that they found. And they ran some blood tests and I got a call from my GP saying that she had found this protein in my blood, which turned out to be multiple myeloma, and that was a cancer. Of course, the idea that I had a cancer in my blood was horrifying. I was in shock for a while—I couldn’t tell people about it.

I had different treatments and then EMPLICITI with Pomalyst and dexamethasone. I’m not really sure what’s coming up next. But I see a lot of possibilities. I’m just going to keep on going.

Florence’s Story DINAH’S FRIEND

When the symptoms became obvious, Dinah came to me and she started the question of would I be one of her primary caretakers. It was a Saturday morning, she called me up. She started to speak, I said just cut to the chase, the answer is yes. Why not? I love you dearly, you’re like a sister to me.

Susan's Story DINAH’S SISTER

Dinah has always been extremely strong. She had the point where she broke down, but then she got back up and said, I’m going to do what it takes. It never really defeated her. She just kept going. I admire her—she’s just amazing.

Angela's Story EMPLICITI PATIENTAngela takes EMPLICITI + Revlimid® (lenalidomide) + dexamethasone


I get along great with the doctors and the nurses. The nurses I see regularly are so supportive. They talk to me about their families, how their new babies are doing, their kids...and whenever I see one of my doctors she always gives me the thumbs up. I respect them, I think they're great, I think they're brilliant, and I feel like my clinic is nearly a home away from home. I couldn’t ask for a better team of nurses and doctors.

My best friend Wade really helped me through my diagnosis and treatment. He supports me and makes me laugh along the way. We talk and laugh, even when we are sitting in the waiting room for my treatments. We have a good time together as friends. That’s always been our normal routine, so that’s what makes me feel the most comfortable through it all. I don’t know what I’d have done without having Wade by my side.


I believe it’s my job to hold her up whenever she needs me to. She’s done the same for me for years, so it was just something I did without even thinking about it.

Rick’s StoryEMPLICITI PATIENTRick takes EMPLICITI + Revlimid® (lenalidomide) + dexamethasone


I grew up with a big backyard and so I was always off having adventures outside. When things get tough, the woods have always been there for me. Fishing, being outside and enjoying nature—all of those things are like therapy for me. I think my family, faith, and nature are the most important things in life, so I don’t sweat the small stuff. No matter what you can't quit. You have to keep up the fight. I know that whatever happens next, I will keep fighting. Nothing is worth giving up.

Denise's Story RICK'S WIFE

Being a caregiver feels like I’m going through everything, too. I just jump right in and don’t give up. You have to just be strong and keep the faith. We’re going to get through this, and even if you don’t believe it, you’ve got to act like you do. I do believe it though.

Hilde's Story EMPLICITI PATIENTHilde takes EMPLICITI + Revlimid® (lenalidomide) + dexamethasone


When I was diagnosed with multiple myeloma, I received chemotherapy and then a stem cell transplant. I was home for 9 months after that, and then I was in remission for about 7 years. Then I had a relapse, so I had to see what options were available to me. The doctor who was treating me for the cancer told me about EMPLICITI combined with Revlimid and dexamethasone. Without my family I don’t think I could have made it through the journey because it was so hard on everybody. My son Tom, who was just married at the time I was diagnosed, did everything to help me including coming to live with me all the way from New York to Wisconsin. He took me to all my appointments and cooked for me.

I'm retired now and the daily things that I do are cooking, reading, and gardening, and doing things with my dog and the grandkids. I look at the world and at my kids and the grandkids and my husband, everything that happens to me—it all has a deeper meaning than things had before.

Tom's Story Hilde’s son

Taking care of my mom was one of the most meaningful and fulfilling things I could have done for her. My mom did everything for me, all the way from high school into college—she made sure that I got to eat, got me to school, and she never hesitated to sacrifice everything for me. So, when it came time for me to drop everything that I was doing, I was extremely happy to do it because she was always there for me.

Randy’s Story EMPLICITI PATIENTRandy takes EMPLICITI + Revlimid® (lenalidomide) + dexamethasone


When I was first diagnosed, I thought I had a torn rotator cuff. It turned out that I had multiple myeloma. Here I am, 41 years old, wife and two kids, and a relatively active life. There was a lot of fear, a lot of anxiety, a lot of uncertainty around what was going to happen and what the future held for my family and myself.

What's important is what you have around you and the attitude that you take. I had a very positive attitude, and I still do, and that was very important to me. I think it helped me get through a lot. I made one promise to both my kids, and that's that I would be honest with them. I think that honesty helped them understand that they were part of this, that they could be a part of this journey that we were going to be on as a family, and that they could ask me any question.

Dana's Story Randy’s wife

Having a loved one with multiple myeloma and being the person that takes care of them changes a person, and it's not always negative. Just like the person with multiple myeloma looks at things differently, so does the caregiver. I look at things daily through a different lens. I'm thankful every day for the things that I was not thankful for before, just the little things that you're happy for that before didn't matter. Since Randy's been diagnosed, he inspires me every day—being able to deal with how he was feeling, and still being there for our kids and myself.

US Full Prescribing Information
Would You Like to Share Your Story?

Your story matters—and it may help someone through their own. Plus, it may give you the opportunity to share your thoughts on materials we’re developing or be featured in some of them. If you or a loved one is interested in sharing your experience on treatment, call 1-855-436-5866.

Learn more about EMPLICITI

See how EMPLICITI has helped patients in clinical studies.


Important Facts About EMPLICITI® (elotuzumab)

EMPLICITI in combination with
Revlimid® (lenalidomide) and dexamethasone or in combination with Pomalyst® (pomalidomide) and dexamethasone may cause the following serious side effects:
Infusion reactions, infections, risk of developing new cancers (malignancies), and liver problems. There are also other serious risks associated with Revlimid and Pomalyst to females and males of reproductive potential, including possible serious birth defects or death of an unborn baby, and specific requirements regarding birth control, pregnancy testing and blood and/or sperm donation. For more information, please read the Important Facts throughout this website or by expanding this section. Your healthcare team will work with you to manage any side effects you may experience throughout your treatment with EMPLICITI.

This is a summary of important information that you need to know about EMPLICITI. Your healthcare team can work with you to help answer any questions you may have about EMPLICITI.

Keep this information in a safe place, so you can refer to it before and during your treatment. Look out for these icons as you read:

Talk to your healthcare teamCall a healthcare provider right awayHelpful information to remember

EMPLICITI is a prescription medicine used with other medications to treat the following types of adult patients with multiple myeloma:

People who have received 1-3 prior treatments for their multiple myeloma may receive:


People who have received at least 2 prior treatments, including Revlimid and a proteasome inhibitor, may receive:


Remember to read the safety information for the other medications you are receiving.

The safety and effectiveness of EMPLICITI have not been studied in children.

What are the possible side effects of EMPLICITI?

EMPLICITI may cause side effects, some of which can be serious. Your healthcare team will work with you to manage any side effects you may experience throughout your treatment with EMPLICITI.

Serious side effects

Infusion reactions can happen during your EMPLICITI infusion or within 24 hours after your infusion. Symptoms of an infusion reaction may include:

  • fever
  • chills
  • rash
  • chest pain
  • trouble breathing
  • dizziness
  • light-headedness

Before every EMPLICITI infusion, your healthcare team will give you medications to help lower your chances of having an infusion reaction. If you have an infusion reaction while receiving EMPLICITI, your healthcare provider will slow or stop your infusion and treat your reaction. If you have a severe infusion reaction, your healthcare provider may decide to stop all your EMPLICITI infusions.

Call your healthcare provider or get medical help right away if you have any of the above symptoms after your infusion with EMPLICITI.

Infections may occur in patients who receive EMPLICITI + Revlimid + dexamethasone or EMPLICITI + Pomalyst + dexamethasone and can be serious. Symptoms of an infection may include:

  • fever
  • flu-like symptoms
  • cough
  • shortness of breath
  • burning with urination
  • painful skin rash

Call a healthcare provider right away if you have any signs or symptoms of an infection.

Developing new cancers (malignancies) is a risk in patients who receive EMPLICITI with Revlimid + dexamethasone or EMPLICITI with Pomalyst + dexamethasone. Your healthcare provider will check you for new cancers during your treatment with EMPLICITI.

Talk to your healthcare team to learn more about your risk of developing new cancers if you receive EMPLICITI.

Liver problems may occur. Symptoms of liver problems include:

  • tiredness
  • weakness
  • loss of appetite
  • yellowing of your skin or eyes
  • color changes in your stools
  • confusion
  • swelling of the stomach area

Your healthcare provider will do blood tests to check your liver during your treatment with EMPLICITI.

Talk to your healthcare team if you have any signs or symptoms of liver problems.

The most common side effects

The most common side effects of EMPLICITI when used with Revlimid + dexamethasone include:

  • fatigue
  • diarrhea
  • fever
  • constipation
  • cough
  • numbness, weakness, tingling, or burning pain in your arms or legs
  • sore throat or runny nose
  • upper respiratory tract infection
  • decreased appetite
  • pneumonia

The most common side effects of EMPLICITI when used with Pomalyst + dexamethasone include:

  • constipation
  • high blood sugar

These are not all of the possible side effects of EMPLICITI.

Call your doctor for medical advice about side effects.

You can report any side effects you experience to the FDA by calling

What should I discuss with my healthcare team before starting EMPLICITI?

Talk to your healthcare team about all of your medical conditions, including if you have an infection.

Let your healthcare team know as soon as possible if you are pregnant, planning to become pregnant, breastfeeding, or planning to breastfeed. It is not known if EMPLICITI can harm an unborn baby. However, Revlimid and Pomalyst may cause birth defects or death of an unborn baby. It is not known if EMPLICITI passes into breastmilk. You should not breastfeed during treatment with EMPLICITI + Revlimid + dexamethasone or with EMPLICITI + Pomalyst + dexamethasone.

Before receiving EMPLICITI + Revlimid + dexamethasone, or EMPLICITI + Pomalyst + dexamethasone, females and males must agree to the instructions in the Revlimid REMS® program or the Pomalyst REMS® program, depending on which combination was prescribed for you. The programs have specific requirements about birth control (contraception), pregnancy testing, blood donation, and sperm donation that you need to know.

Talk to your healthcare team to learn more about Revlimid or Pomalyst.

Interactions with other drugs may affect the way EMPLICITI works in your body.

Talk to your healthcare team about all the medicines you take, including:

  • prescription medicines
  • over-the-counter medicines
  • vitamins
  • herbal supplements

Please read the Patient Information in the Full Prescribing Information.

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